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HRK (gene)
・ HRK Izviđač
・ Hrkljuš
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・ HRL Laboratories
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・ HRN
・ Hrnčiarovce nad Parnou
・ Hrnčiarska Ves
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・ Hrnčići
・ Hrnčár
・ HRO


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HRK (gene) : ウィキペディア英語版
HRK (gene)

Activator of apoptosis harakiri is a protein that in humans is encoded by the ''HRK'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8739 )
== Function ==

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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